She has been treated by this clinic since birth. I am so worried about her I called to explain and was told to feed her chicken and rice and if she isn't improved take her to Emergency Vet Hospital. I wish every one the best. She nearly died. Tick titer came back a light positive which lab said was specifically false due to the recent lyme x2 booster i was scared in to giving. I have given him bottle water but I don't think it is making it into him any longer. Hello to everyone and I am so sorry we had to meet under these circumstances. Her poor top underside of her tail has raw skin the hair is completely gone like burnt off from diarrhea. He was a dog you could pick up anytime and he was good as gold. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. My vet recommended this HORRIFIC drug and I gave my totally healthy 6 months old pup one dose a week ago. I'll be spreading the word. Same as you describe. But I noticed that I had to "wake him' several times in only 2 minutes time, but he wasn't sleeping, his eyes were open and I saw them rolling in the back of his head! He had ONE dose that evening and completely lost his appetite within a couple days. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. She is lethargic and doesnt want to eat. I hope it has no permanent impact on him. Product Overview. He is sometimes picky with his food, so I mixed in some green beans, etc but he stopped eating anything and had bright orange diarrhea by the 31st. I hope I have found the culprit to his digression. Lost all appetite. Mine has tremors once in a while and now I know why! I am convinced this medicine is HORRIBLE and is causing this. So no Addisions. This went on for 4 hours. She wanted me to monitor him carefully and wait to see how he did on his next dose of Simparica before continuing to prescribe it. This is an eye opener for me! Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. Thankfully there have been no other side effects. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. We did get a little symptom improvement from prednisone if they are having other neurological issues. Twice I have seen his eyes roll into the back of his head (petti-mal seizure?) Will this ever get better as the med wears down? Will it get worse Will he get better? So here we are on the 2nd dose. The issues started within 24 hours of the dose and continue. They can also have major side effects. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. They said , he has a Autoimmune Hemolytic anemia . Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. He had soft poop right after I give him the pill then got worse yellow diarrhea for about a week also vomiting he fine now they changed the medication. I am so mad at myself for letting the vet talk me into this. Vet said if she vomits bring her in. No more itching but covered in same scabs. I would not recommend giving Simparica to your pets!!!!! I feel like she's been an experiment to make others money. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. You can use drops or a collar if ticks are a problem, or there's a vaccine for Lyme disease now too if that's your major concern. We think that the drug is the cause of the seizures . He first started with seizures and losing weight in June after giving him Simparica. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. Each medication combats different pests. She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. I feel the manufacturer should pay my test bills and meds .. my doc talked me into this regimine of meds and my previous dog did well on sorresto color and heart word med .. any clue on who I contact ? I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! However, they are possible, so it is better to know they might happen. Youre an idiot then! She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. I am currently in the same situation and we are at day 16 after giving simparica. I read all the above and it makes me sad. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! The day after administering drug he had two incapacitating seizures. From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. In addition to the tremors, have you noticed any . There was no clear diagnosis but it was clearly neurological. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. The vet has not been able to diagnose a cause. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. Gave this to my dogs and now he sleeps all the time and tired and has symptoms now like droopy right side weakness cant blink right eye and drooling like bells palsy. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. My 5 year old, healthy Australian Shepherd had a check-up + boosters at the vet on January 24th. Im so angry at these drug companies and vets for selling this crap. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. That night he seemed a little uncomfortable, unable to sleep, and I didnt think anything of it. The only thing we changed after his checkup if Feb. was his flea and tick treatment. Just had my 1 yr old goldendoodle to the vet because he has had 3 seizures in the last month. I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. Then gave me pills of prednisone for him to take 1 pill twice a day . Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . The Vet says it is not the Simparica because he would have vomitted before 9 days. Considerations Just like any other medication, Simparica has the potential to interact with other drugs your dog is taking. Them I took him to a vet for check up and to my horror, he has fleas and a tick. He has never done this, and when I heard it and woke up he couldn't stop. I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. They would clear up after a round of antibiotics but would return the next month. My lab puppies have been taking Simparica Trio for 2 months. About 11 months ago our vet recommended Simparica Trio. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. I wouldnt have given it to her. I took her home. The exact same thing is happening to my dog now. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. I got my dog Josey up to let him out to pee. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. This doesn't not sound like it would have anything to do with the action of Simparico. I should have kept with my gut feeling about any of these oral meds. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! It is like night and day compared to her regular personality or demeanor. Another call to vet asking for an appt - seems like an an emergency now? First dose was on 4/1 and 9 days later he was vomiting goop (yellow thick goo), he would drink water and vomit. The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. For 5 years I have resisted my veterinarians suggestions for oral flea meds. The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. Poor baby has had vomiting and diarrhoea ever since. Ekko then started having seizures in May,June and July. The door is open , its where he prefers to sleep on a doggie bed . Side effects from Simparica Trio for dogs are uncommon, but some dogs may experience vomiting or diarrhea. Bentlee trusts me an I let him down on this one. I hope this comment will save you and your pets from unnecessary trouble. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. Instead, it kills larvae, allowing your dog to avoid infection. Will not use this again and will warn others. However, the product has not been evaluated in breeding, pregnant, or lactating dogs. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. Shame on you! He took simparica trio 3 weeks ago and I cant wait until its out of his system! It went away, I thought the diarrhea was from some of the junk she eats off of the ground. Sarolaner is also used in combination products for both dogs and cats. I even said "I am reading a blog, right now, with pages of stories about this drug and the side effects". Reading all of these comments I too think it is the drug that has caused his body to be toxic for him. Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. She is still eating but she is drinking more water. My family saw it , I did not . Did you ever get to the bottom of redness in eyes? 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